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Workshop on Varcode

Workshop on Varcode

Oct 13, 2022 | ,

Today we begin our varcode training with Dr. Anita Ghanasah and  Dr. Kathryn Tiedje. Dr Kathryn Tiedje is a Research Fellow working in the laboratory of Prof. Karen Day based in the Peter Doherty and Bio21 Institutes at The University of Melbourne, AU. Kathryn is an...

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Meeting with NMCP

Meeting with NMCP

Oct 13, 2022 |

The National Malaria Control Programme (NMCP) in collaboration with the Noguchi Memorial Institute for Medical Research (NMIMR) have worked together for many years to control Malaria in Ghana. Earlier this year, the NMCP gave the Ghansahlab the opportunity to...

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Congratulations Rita!

Congratulations Rita!

Sep 30, 2022 |

Rita Afriyie Boateng was awarded a Ph.D. degree in computational biology and bioinformatics from Rhodes University, South Africa in April 2022. This was made possible with the guidance of Dr Anita Ghansah and her school supervisors over the course of three and half...

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publications External ResourceS

The complete sequence of a human genome

Author(s)
Sergey Nurk, Sergey Koren, Arang Rhie, Mikko Rautiainen, Jennifer McDaniel, Nathanael David Olson, Justin Wagner, Justin Zook, Evan Eichler, Karen Miga, Adam Phillippy
Since its initial release in 2000, the human reference genome has covered only the euchromatic fraction of the genome, leaving important heterochromatic regions

RNA reference materials with defined viral RNA loads of SARS-CoV-2 – A useful tool towards a better PCR assay harmonization

Author(s)
Laura Vierbaum, Nathalie Wojtalewicz, Vanessa Lindig, Ulf Dühring, Hans-Peter Grunert, Christian Drosten, Victor Corman, Daniela Niemeyer, Sandra Ciesek, Holger Rabenau, Annemarie Berger, Martin Obermeier, Andreas Nitsche, Janine Michel, Martin Mielke, Jim Huggett, Denise O’Sullivan, Simon Cowen, Megan Cleveland, Peter Vallone, Samreen Falak, Andreas Kummrow, Thomas Keller, Ingo Schellenberg, Heinz Zeichhardt, Martin Kammel
The outbreak and pandemic spread of SARS-CoV-2, the cause of the novel coronavirus disease (COVID-19), led to the need for a reliable detection method to track
Enninful KS, Kwofie SK, Tetteh-Tsifoanya M, Lamptey ANL, Djameh G, Nyarko S, Ghansah A, Wilson MD. Targeting the Plasmodium falciparum‘s Thymidylate Monophosphate Kinase for the Identification of Novel Antimalarial Natural Compounds. Front Cell Infect Microbiol. 2022;12:868529. doi: 10.3389/fcimb.2022.868529. eCollection 2022. PubMed PMID: 35694550; PubMed Central PMCID: PMC9174469.
Tiedje KE, Oduro AR, Bangre O, Amenga-Etego L, Dadzie SK, Appawu MA, Frempong K, Asoala V, Ruybal-Pésantez S, Narh CA, Deed SL, Argyropoulos DC, Ghansah A, Agyei SA, Segbaya S, Desewu K, Williams I, Simpson JA, Malm K, Pascual M, Koram KA, Day KP. Indoor residual spraying with a non-pyrethroid insecticide reduces the reservoir of Plasmodium falciparum in a high-transmission area in northern Ghana. PLOS Glob Public Health. 2022;2(5). doi: 10.1371/journal.pgph.0000285. Epub 2022 May 18. PubMed PMID: 35600674; PubMed Central PMCID: PMC9121889.
Kisiangani I, Mohamed SF, Kyobutungi C, Tindana P, Ghansah A, Ramsay M, Asiki G. Perspectives on returning individual and aggregate genomic research results to study participants and communities in Kenya: a qualitative study. BMC Med Ethics. 2022 Mar 18;23(1):27. doi: 10.1186/s12910-022-00767-y. PubMed PMID: 35300680; PubMed Central PMCID: PMC8932129.
Aydemir O, Mensah B, Marsh PW, Abuaku B, Myers-Hansen JL, Bailey JA, Ghansah A. Immediate pools of malaria infections at diagnosis combined with targeted deep sequencing accurately quantifies frequency of drug resistance mutations. PeerJ. 2021;9:e11794. doi: 10.7717/peerj.11794. eCollection 2021. PubMed PMID: 34820155; PubMed Central PMCID: PMC8588852.
Mensah BA, Myers-Hansen JL, Obeng Amoako E, Opoku M, Abuaku BK, Ghansah A. Prevalence and risk factors associated with asymptomatic malaria among school children: repeated cross-sectional surveys of school children in two ecological zones in Ghana. BMC Public Health. 2021 Sep 17;21(1):1697. doi: 10.1186/s12889-021-11714-8. PubMed PMID: 34535112; PubMed Central PMCID: PMC8447720.
Ndwiga L, Kimenyi KM, Wamae K, Osoti V, Akinyi M, Omedo I, Ishengoma DS, Duah-Quashie N, Andagalu B, Ghansah A, Amambua-Ngwa A, Tukwasibwe S, Tessema SK, Karema C, Djimde AA, Dondorp AM, Raman J, Snow RW, Bejon P, Ochola-Oyier LI. A review of the frequencies of Plasmodium falciparum Kelch 13 artemisinin resistance mutations in Africa. Int J Parasitol Drugs Drug Resist. 2021 Aug;16:155-161. doi: 10.1016/j.ijpddr.2021.06.001. Epub 2021 Jun 10. Review. PubMed PMID: 34146993; PubMed Central PMCID: PMC8219943.
Anie KA, Olayemi E, Paintsil V, Owusu-Dabo E, Adeyemo TA, Sani MU, Galadanci NA, Nnodu O, Tluway F, Adjei DN, Mensah P, Sarfo-Antwi J, Nwokobia H, Gambo A, Benjamin A, Salim A, Osae-Larbi JA, Ofori-Acquah SF. Sickle Cell Disease Genomics of Africa (SickleGenAfrica) Network: ethical framework and initial qualitative findings from community engagement in Ghana, Nigeria and Tanzania. BMJ Open. 2021 Jul 23;11(7):e048208. doi: 10.1136/bmjopen-2020-048208. PubMed PMID: 34301659; PubMed Central PMCID: PMC8311318.
Muriuki BM, Forconi CS, Oluoch PO, Bailey JA, Ghansah A, Moormann AM, Ong’echa JM. Association of killer cell immunoglobulin-like receptors with endemic Burkitt lymphoma in Kenyan children. Sci Rep. 2021 May 31;11(1):11343. doi: 10.1038/s41598-021-90596-7. PubMed PMID: 34059753; PubMed Central PMCID: PMC8166913.
Brown CA, Pappoe-Ashong PJ, Duah N, Ghansah A, Asmah H, Afari E, Koram KA. High frequency of the Duffy-negative genotype and absence of Plasmodium vivax infections in Ghana. Malar J. 2021 Feb 17;20(1):99. doi: 10.1186/s12936-021-03618-0. PubMed PMID: 33596926; PubMed Central PMCID: PMC7888148.
Ofori MF, Kploanyi EE, Mensah BA, Dickson EK, Kyei-Baafour E, Gyabaa S, Tetteh M, Koram KA, Abuaku BK, Ghansah A. Ex vivo Sensitivity Profile of Plasmodium falciparum Clinical Isolates to a Panel of Antimalarial Drugs in Ghana 13 Years After National Policy Change. Infect Drug Resist. 2021;14:267-276. doi: 10.2147/IDR.S295277. eCollection 2021. PubMed PMID: 33536768; PubMed Central PMCID: PMC7850388.
Myers-Hansen JL, Abuaku B, Oyebola MK, Mensah BA, Ahorlu C, Wilson MD, Awandare G, Koram KA, Ngwa AA, Ghansah A. Assessment of antimalarial drug resistant markers in asymptomatic Plasmodium falciparum infections after 4 years of indoor residual spraying in Northern Ghana. PLoS One. 2020;15(12):e0233478. doi: 10.1371/journal.pone.0233478. eCollection 2020. PubMed PMID: 33284800; PubMed Central PMCID: PMC7721464.
Amegashie EA, Amenga-Etego L, Adobor C, Ogoti P, Mbogo K, Amambua-Ngwa A, Ghansah A. Population genetic analysis of the Plasmodium falciparum circumsporozoite protein in two distinct ecological regions in Ghana. Malar J. 2020 Nov 27;19(1):437. doi: 10.1186/s12936-020-03510-3. PubMed PMID: 33246470; PubMed Central PMCID: PMC7694917.
Narh CA, Ghansah A, Duffy MF, Ruybal-Pesántez S, Onwona CO, Oduro AR, Koram KA, Day KP, Tiedje KE. Evolution of Antimalarial Drug Resistance Markers in the Reservoir of Plasmodium falciparum Infections in the Upper East Region of Ghana. J Infect Dis. 2020 Oct 13;222(10):1692-1701. doi: 10.1093/infdis/jiaa286. PubMed PMID: 32459360; PubMed Central PMCID: PMC7982568.
Agamah FE, Mazandu GK, Hassan R, Bope CD, Thomford NE, Ghansah A, Chimusa ER. Computational/in silico methods in drug target and lead prediction. Brief Bioinform. 2020 Sep 25;21(5):1663-1675. doi: 10.1093/bib/bbz103. Review. PubMed PMID: 31711157; PubMed Central PMCID: PMC7673338.
Kofi AE, Hakim HM, Khan HO, Ismail SA, Ghansah A, Haslindawaty ARN, Shamsuddin S, Aziz MY, Chambers GK, Edinur HA. Population dataset for 21 simple tandem repeat loci in the Akan population of Ghana. Data Brief. 2020 Aug;31:105746. doi: 10.1016/j.dib.2020.105746. eCollection 2020 Aug. PubMed PMID: 32490095; PubMed Central PMCID: PMC7262416.
Kofi AE, Hakim HM, Khan HO, Ismail SA, Ghansah A, David AA, Mat NFC, Chambers GK, Edinur HA. Population data of 23 Y chromosome STR loci for the five major human subpopulations of Ghana. Int J Legal Med. 2020 Jul;134(4):1313-1315. doi: 10.1007/s00414-019-02099-w. Epub 2019 Jun 1. PubMed PMID: 31154498.
Verity R, Aydemir O, Brazeau NF, Watson OJ, Hathaway NJ, Mwandagalirwa MK, Marsh PW, Thwai K, Fulton T, Denton M, Morgan AP, Parr JB, Tumwebaze PK, Conrad M, Rosenthal PJ, Ishengoma DS, Ngondi J, Gutman J, Mulenga M, Norris DE, Moss WJ, Mensah BA, Myers-Hansen JL, Ghansah A, Tshefu AK, Ghani AC, Meshnick SR, Bailey JA, Juliano JJ. The impact of antimalarial resistance on the genetic structure of Plasmodium falciparum in the DRC. Nat Commun. 2020 Apr 30;11(1):2107. doi: 10.1038/s41467-020-15779-8. PubMed PMID: 32355199; PubMed Central PMCID: PMC7192906.
Mensah BA, Aydemir O, Myers-Hansen JL, Opoku M, Hathaway NJ, Marsh PW, Anto F, Bailey J, Abuaku B, Ghansah A. Antimalarial Drug Resistance Profiling of Plasmodium falciparum Infections in Ghana Using Molecular Inversion Probes and Next-Generation Sequencing. Antimicrob Agents Chemother. 2020 Mar 24;64(4). doi: 10.1128/AAC.01423-19. Print 2020 Mar 24. PubMed PMID: 31932374; PubMed Central PMCID: PMC7179265.
Nembaware V, Mulder N. The African Genomic Medicine Training Initiative (AGMT): Showcasing a Community and Framework Driven Genomic Medicine Training for Nurses in Africa. Front Genet. 2019;10:1209. doi: 10.3389/fgene.2019.01209. eCollection 2019. PubMed PMID: 31921282; PubMed Central PMCID: PMC6934054.
Insights into malaria susceptibility using genome-wide data on 17,000 individuals from Africa, Asia and Oceania. Nat Commun. 2019 Dec 16;10(1):5732. doi: 10.1038/s41467-019-13480-z. PubMed PMID: 31844061; PubMed Central PMCID: PMC6914791.
Ghansah A, Kamau E, Amambua-Ngwa A, Ishengoma DS, Maiga-Ascofare O, Amenga-Etego L, Deme A, Yavo W, Randrianarivelojosia M, Ochola-Oyier LI, Helegbe GK, Bailey J, Alifrangis M, Djimde A. Targeted Next Generation Sequencing for malaria research in Africa: current status and outlook. Malar J. 2019 Sep 23;18(1):324. doi: 10.1186/s12936-019-2944-2. PubMed PMID: 31547818; PubMed Central PMCID: PMC6757370.
Amambua-Ngwa A, Amenga-Etego L, Kamau E, Amato R, Ghansah A, Golassa L, Randrianarivelojosia M, Ishengoma D, Apinjoh T, Maïga-Ascofaré O, Andagalu B, Yavo W, Bouyou-Akotet M, Kolapo O, Mane K, Worwui A, Jeffries D, Simpson V, D’Alessandro U, Kwiatkowski D, Djimde AA. Major subpopulations of Plasmodium falciparum in sub-Saharan Africa. Science. 2019 Aug 23;365(6455):813-816. doi: 10.1126/science.aav5427. PubMed PMID: 31439796.
Dzodzomenyo M, Ghansah A, Ensaw N, Dovie B, Bimi L, Quansah R, Gyan BA, Gyakobo M, Amoani B. Inducible nitric oxide synthase 2 promoter polymorphism and malaria disease severity in children in Southern Ghana. PLoS One. 2018;13(8):e0202218. doi: 10.1371/journal.pone.0202218. eCollection 2018. PubMed PMID: 30118498; PubMed Central PMCID: PMC6097674.
Aydemir O, Janko M, Hathaway NJ, Verity R, Mwandagalirwa MK, Tshefu AK, Tessema SK, Marsh PW, Tran A, Reimonn T, Ghani AC, Ghansah A, Juliano JJ, Greenhouse BR, Emch M, Meshnick SR, Bailey JA. Drug-Resistance and Population Structure of Plasmodium falciparum Across the Democratic Republic of Congo Using High-Throughput Molecular Inversion Probes. J Infect Dis. 2018 Aug 14;218(6):946-955. doi: 10.1093/infdis/jiy223. PubMed PMID: 29718283; PubMed Central PMCID: PMC6093412.
Ndila CM, Uyoga S, Macharia AW, Nyutu G, Peshu N, Ojal J, Shebe M, Awuondo KO, Mturi N, Tsofa B, Sepúlveda N, Clark TG, Band G, Clarke G, Rowlands K, Hubbart C, Jeffreys A, Kariuki S, Marsh K, Mackinnon M, Maitland K, Kwiatkowski DP, Rockett KA, Williams TN. Human candidate gene polymorphisms and risk of severe malaria in children in Kilifi, Kenya: a case-control association study. Lancet Haematol. 2018 Aug;5(8):e333-e345. doi: 10.1016/S2352-3026(18)30107-8. Epub 2018 Jul 20. PubMed PMID: 30033078; PubMed Central PMCID: PMC6069675.
Ghouila A, Siwo GH, Entfellner JD, Panji S, Button-Simons KA, Davis SZ, Fadlelmola FM, Ferdig MT, Mulder N. Hackathons as a means of accelerating scientific discoveries and knowledge transfer. Genome Res. 2018 May;28(5):759-765. doi: 10.1101/gr.228460.117. Epub 2018 Apr 12. PubMed PMID: 29650552; PubMed Central PMCID: PMC5932615.
Rorick MM, Artzy-Randrup Y, Ruybal-Pesántez S, Tiedje KE, Rask TS, Oduro A, Ghansah A, Koram K, Day KP, Pascual M. Signatures of competition and strain structure within the major blood-stage antigen of Plasmodium falciparum in a local community in Ghana. Ecol Evol. 2018 Apr;8(7):3574-3588. doi: 10.1002/ece3.3803. eCollection 2018 Apr. PubMed PMID: 29686839; PubMed Central PMCID: PMC5901166.
Ruybal-Pesántez S, Tiedje KE, Rorick MM, Amenga-Etego L, Ghansah A, R Oduro A, Koram KA, Day KP. Lack of Geospatial Population Structure Yet Significant Linkage Disequilibrium in the Reservoir of Plasmodium falciparum in Bongo District, Ghana. Am J Trop Med Hyg. 2017 Oct;97(4):1180-1189. doi: 10.4269/ajtmh.17-0119. Epub 2017 Jul 19. PubMed PMID: 28722587; PubMed Central PMCID: PMC5637601.
Abuaku BK, Mensah BA, Ofori MF, Myers-Hansen J, Derkyi-Kwarteng AN, Essilfie F, Dokurugu M, Amoakoh E, Koram KA, Ghansah A. Efficacy of Artesunate/Amodiaquine in the Treatment of Uncomplicated Malaria among Children in Ghana. Am J Trop Med Hyg. 2017 Sep;97(3):690-695. doi: 10.4269/ajtmh.15-0826. Epub 2017 Jul 27. PubMed PMID: 28749762; PubMed Central PMCID: PMC5590557.
Asare EV, Olayemi E, Boafor T, Dei-Adomakoh Y, Mensah E, Ghansah H, Osei-Bonsu Y, Crabbe S, Musah L, Hayfron-Benjamin C, Covert B, Kassim AA, James A, Rodeghier M, DeBaun MR, Oppong SA. Implementation of multidisciplinary care reduces maternal mortality in women with sickle cell disease living in low-resource setting. Am J Hematol. 2017 Sep;92(9):872-878. doi: 10.1002/ajh.24790. Epub 2017 Jun 9. PubMed PMID: 28512745; PubMed Central PMCID: PMC7725481.
Tiedje KE, Oduro AR, Agongo G, Anyorigiya T, Azongo D, Awine T, Ghansah A, Pascual M, Koram KA, Day KP. Seasonal Variation in the Epidemiology of Asymptomatic Plasmodium falciparum Infections across Two Catchment Areas in Bongo District, Ghana. Am J Trop Med Hyg. 2017 Jul;97(1):199-212. doi: 10.4269/ajtmh.16-0959. PubMed PMID: 28719306; PubMed Central PMCID: PMC5508908.
Clarke GM, Rockett K, Kivinen K, Hubbart C, Jeffreys AE, Rowlands K, Jallow M, Conway DJ, Bojang KA, Pinder M, Usen S, Sisay-Joof F, Sirugo G, Toure O, Thera MA, Konate S, Sissoko S, Niangaly A, Poudiougou B, Mangano VD, Bougouma EC, Sirima SB, Modiano D, Amenga-Etego LN, Ghansah A, Koram KA, Wilson MD, Enimil A, Evans J, Amodu OK, Olaniyan S, Apinjoh T, Mugri R, Ndi A, Ndila CM, Uyoga S, Macharia A, Peshu N, Williams TN, Manjurano A, Sepúlveda N, Clark TG, Riley E, Drakeley C, Reyburn H, Nyirongo V, Kachala D, Molyneux M, Dunstan SJ, Phu NH, Quyen NN, Thai CQ, Hien TT, Manning L, Laman M, Siba P, Karunajeewa H, Allen S, Allen A, Davis TM, Michon P, Mueller I, Molloy SF, Campino S, Kerasidou A, Cornelius VJ, Hart L, Shah SS, Band G, Spencer CC, Agbenyega T, Achidi E, Doumbo OK, Farrar J, Marsh K, Taylor T, Kwiatkowski DP. Characterisation of the opposing effects of G6PD deficiency on cerebral malaria and severe malarial anaemia. Elife. 2017 Jan 9;6. doi: 10.7554/eLife.15085. PubMed PMID: 28067620; PubMed Central PMCID: PMC5222559.
Oyola SO, Ariani CV, Hamilton WL, Kekre M, Amenga-Etego LN, Ghansah A, Rutledge GG, Redmond S, Manske M, Jyothi D, Jacob CG, Otto TD, Rockett K, Newbold CI, Berriman M, Kwiatkowski DP. Whole genome sequencing of Plasmodium falciparum from dried blood spots using selective whole genome amplification. Malar J. 2016 Dec 20;15(1):597. doi: 10.1186/s12936-016-1641-7. PubMed PMID: 27998271; PubMed Central PMCID: PMC5175302.
Kwofie KD, Ghansah A, Osei JH, Frempong KK, Obed S, Frimpong EH, Boakye DA, Suzuki T, Ohta N, Ayi I. Indication of Risk of Mother-to-Child Toxoplasma gondii Transmission in the Greater Accra Region of Ghana. Matern Child Health J. 2016 Dec;20(12):2581-2588. doi: 10.1007/s10995-016-2084-z. PubMed PMID: 27465060.
Sam-Agudu NA, Paintsil E, Aliyu MH, Kwara A, Ogunsola F, Afrane YA, Onoka C, Awandare GA, Amponsah G, Cornelius LJ, Mendy G, Sturke R, Ghansah A, Siberry GK, Ezeanolue EE. Building Sustainable Local Capacity for Global Health Research in West Africa. Ann Glob Health. 2016 Nov – Dec;82(6):1010-1025. doi: 10.1016/j.aogh.2016.10.011. PubMed PMID: 28314488.
Busby GB, Band G, Si Le Q, Jallow M, Bougama E, Mangano VD, Amenga-Etego LN, Enimil A, Apinjoh T, Ndila CM, Manjurano A, Nyirongo V, Doumba O, Rockett KA, Kwiatkowski DP, Spencer CC. Admixture into and within sub-Saharan Africa. Elife. 2016 Jun 21;5. doi: 10.7554/eLife.15266. PubMed PMID: 27324836; PubMed Central PMCID: PMC4915815.
Ayi I, Kwofie KD, Blay EA, Osei JH, Frempong KK, Koku R, Ghansah A, Lartey M, Suzuki T, Boakye DA, Koram KA, Ohta N. Clonal types of Toxoplasma gondii among immune compromised and immune competent individuals in Accra, Ghana. Parasitol Int. 2016 Jun;65(3):238-44. doi: 10.1016/j.parint.2016.01.004. Epub 2016 Jan 8. PubMed PMID: 26775819.
Osafo C, Raji YR, Burke D, Tayo BO, Tiffin N, Moxey-Mims MM, Rasooly RS, Kimmel PL, Ojo A, Adu D, Parekh RS. Human Heredity and Health (H3) in Africa Kidney Disease Research Network: A Focus on Methods in Sub-Saharan Africa. Clin J Am Soc Nephrol. 2015 Dec 7;10(12):2279-87. doi: 10.2215/CJN.11951214. Epub 2015 Jul 2. PubMed PMID: 26138261; PubMed Central PMCID: PMC4670777.
Blay EA, Ghansah A, Otchere J, Koku R, Kwofie KD, Bimi L, Takashi S, Ohta N, Ayi I. Congenital toxoplasmosis and pregnancy malaria detection post-partum: Effective diagnosis and its implication for efficient management of congenital infection. Parasitol Int. 2015 Dec;64(6):603-8. doi: 10.1016/j.parint.2015.08.004. Epub 2015 Aug 8. PubMed PMID: 26264261.
Band G, Rockett KA, Spencer CC, Kwiatkowski DP. A novel locus of resistance to severe malaria in a region of ancient balancing selection. Nature. 2015 Oct 8;526(7572):253-7. doi: 10.1038/nature15390. Epub 2015 Sep 30. PubMed PMID: 26416757; PubMed Central PMCID: PMC4629224.
Uyoga S, Ndila CM, Macharia AW, Nyutu G, Shah S, Peshu N, Clarke GM, Kwiatkowski DP, Rockett KA, Williams TN. Glucose-6-phosphate dehydrogenase deficiency and the risk of malaria and other diseases in children in Kenya: a case-control and a cohort study. Lancet Haematol. 2015 Oct;2(10):e437-44. doi: 10.1016/S2352-3026(15)00152-0. Epub 2015 Sep 22. PubMed PMID: 26686045; PubMed Central PMCID: PMC4703047.
Kamau E, Campino S, Amenga-Etego L, Drury E, Ishengoma D, Johnson K, Mumba D, Kekre M, Yavo W, Mead D, Bouyou-Akotet M, Apinjoh T, Golassa L, Randrianarivelojosia M, Andagalu B, Maiga-Ascofare O, Amambua-Ngwa A, Tindana P, Ghansah A, MacInnis B, Kwiatkowski D, Djimde AA. K13-propeller polymorphisms in Plasmodium falciparum parasites from sub-Saharan Africa. J Infect Dis. 2015 Apr 15;211(8):1352-5. doi: 10.1093/infdis/jiu608. Epub 2014 Nov 2. PubMed PMID: 25367300; PubMed Central PMCID: PMC4827505.
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